Regulation of early growth response 2 expression by secreted frizzled related protein 1
نویسندگان
چکیده
منابع مشابه
FrzA, a secreted frizzled related protein, induced angiogenic response.
BACKGROUND The secreted frizzled related proteins (sFRP) are soluble proteins thought to interfere with the Wnt signaling. Our group previously demonstrated that one of these members, sFRP-1/FrzA, is strongly expressed during early phases of the vascularization process in embryonic vasculature and in the endothelium of arteries and capillaries in adults and modulated vascular cell proliferation...
متن کاملSecreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response.
OBJECTIVE The inflammatory response after myocardial infarction plays a crucial role in the healing process. Lately, there is accumulating evidence that the Wnt/Frizzled pathway may play a distinct role in inflammation. We have shown that secreted frizzled-related protein-1 (sFRP-1) overexpression reduced postinfarction scar size, and we noticed a decrease in neutrophil infiltration in the isch...
متن کاملInvestigation of mRNA expression for secreted frizzled-related protein 2 (sFRP2) in chick embryos.
The roles of secreted frizzled-related protein 2 (sFRP2) in organ development of vertebrate animals are not well understood. We investigated expression of sFRP2 during embryogenesis of Arbor Acre broiler chicken eggs. Expression of sFRP2 was detected in the folds and lateral layer of developing brains. The sFRP2 signals in the developing eye were marked as a circle along the orbit. In younger e...
متن کاملUltrasound Molecular Imaging of Secreted Frizzled Related Protein-2 Expression in Murine Angiosarcoma
Angiosarcoma is a biologically aggressive vascular malignancy with a high metastatic potential. In the era of targeted medicine, knowledge of specific molecular tumor characteristics has become more important. Molecular imaging using targeted ultrasound contrast agents can monitor tumor progression non-invasively. Secreted frizzled related protein 2 (SFRP2) is a tumor endothelial marker express...
متن کاملAltered expression of secreted frizzled-related protein-2 in retinitis pigmentosa retinas.
PURPOSE Inherited retinal degenerations such as retinitis pigmentosa (RP) are characterized by progressive death of the photoreceptors due to apoptosis. To identify changes in gene expression associated with the degenerative state in RP retinas, expression profiling of apoptosis-related genes was performed using a gridded array technique. METHODS Total RNAs from RP and control retinas were us...
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2017
ISSN: 1471-2407
DOI: 10.1186/s12885-017-3426-y